Alzheimer’s Disease
Alzheimer’s disease is a dementia that already has more than 100 years of history. In November 1901 was admitted to hospital for mental diseases Frankfurt a 51-year-old named Auguste Deter (Augusta D), with a striking clinical picture of five years of evolution.
After starting with a Jealous delirium, the patient had suffered a rapid and progressive loss of memory accompanied by hallucinations, disorientation in time and space, paranoia, behavioral disorders and severe language disorder. Was studied by Alois Alzheimer, and later by anonymous doctors. He died on April 8, 1906 by sepsis, secondary to pressure ulcers and pneumonia.
The brain of the patient was sent to Alzheimer, who proceeded to histological study. On November 4, 1906 submitted its anatomical observation with the description of senile plaques, neurofibrillary tangles and arteriosclerotic changes in the brain.